Endocrine Abstracts

Introduction: Clinical practice guidelines on diabetes mellitus (DM) was created by The Society of Endocrinology & Metabolism, Turkey (SEMT). The ADMIRE Project is designed to evaluate the effect of implementation activities to increase physicians’ awareness on guidelines.Methods: A total of 180 physicians from national representative diabetes clinics kept medical records of 885 T2DM patients for 6 months, without any interference to their routi...

Background: Guidelines for management of diabetes mellitus (DM) provide standardization of care and treatment. National clinical practice guidelines on DM have been developed in 2006 by The Society of Endocrinology and Metabolism of Turkey and reviewed annually.Methods: One hundred and eighty physicians evaluated previous 12 months’ medical records of their type 2 DM patients with special emphasis on whether the patients were followed consistently w...

Objective: Thiazolidinediones offer promise as oral insulin-sensitizing agents. Peroxisome proliferator-activated receptor-g (PPARg), a member of the steroid receptor superfamily, play a pivotal role in the differentiation of adipocytic cells. Osteoblasts and adipocytes are derived from common bone marrow stromal cells that play crucial roles in the generation of osteoclasts. Activation of peroxisome proliferator-activated receptor-g (PPARg) induces adipogenic differentiation ...

Objectives-Aim: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. They stumulate atherosclerosis. Glucocorticoids decrease LDL degradation and expression of LDL receptor. Morever insulin resistance in glucocorticoid excess state may contribute to LDL oxidation changes. The aim of this study was to investigate, the LDL oxidation in glucocorticoid excess state and the effect of atorvastatin on LDL oxidation.<p class="...

Objectives-Aim: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. They stumulate atherosclerosis. Oestradiol and other oestrogens have been shown to be powerful antioxidants in vitro when they are added to ldl oxidation mixtures. Oestrogen deficiency states are increases LDL oxidation. The aim of this study is investigate the effect of growth hormone on LDL oxidation in estrogen deficiency.Materia...

Objective: Human growth hormone (hGH) stimulates bone formation and have been proposed as therapeutic agents for osteoporosis. We have examined the effects of hGH on femoral and vertebral bone strength in osteoporotic rats.Methods: Thirty-five Sprague-Dawley rats were assigned to study in three groups: (1) Normal rats (without ovariectomy and corticosteroid therapy) (2) Osteoporosis group: ovariectomized (OVX) or with glucocorticoid induced osteoporotic ...

A 60-year-old woman with a previous history of twice transsphenoidal pituitary surgery due to acromegaly,had a surgery with a presumed diagnosis of bladder stone. She was reevaluated after the surgery when her hematuria persisted. Percutaneous nephrolitotomy was planned. when multiple stones were identified in the left ureter, but the operation had to be postponed till the achievement of glycemic control. At the meantime endocrinological evaluation revealed a 30×15 mm mac...

This study was undertaken to examine the effects of leptin on testicular histology in mice. Animals were divided into two groups. Group I served as controls. Mice in Group II were injected daily with leptin for five days. All animals were killed by decapitation at the end of the experiment. The testes were removed and weighed out. Some of the testicular tissue specimens were used for light and electron microscopic examination. The remaining samples were processed for semiquant...

Objective: Estrogen or raloxifen prevent estrogen deficiency-induced bone loss animals and humans. There is a medical need for agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects tissue. So, we investigated the effects of raloxifen on bone strength and cholesterol levels in osteoporotic rats and compared them with estrogen treatment.Methods: Thirty-one ovariectomized (OVX) Sprague-Dawney ra...

Objective: HMG Coenzyme A reductase inhibitors (statins) mainly decrease low-density lipoproteins (LDL) cholesterol but also have been found to have beneficial effects in the skeleton. The aim of this study was to examine atorvastatin effects in vivo on femoral and vertebral bone strength.Methods: An ovariectomized (OVX), a glucocorticoid induced osteoporotic (GIO) and an OVX plus GIO group of rat models were used to study the effects of atorvastatin. Sp...